Recombinant Human Myosin Light Chain Kinase 2, His-tagged, Active

• Cat.No.: MYLK2-365H
• Product Overview: Recombinant full-length human MYLK2 was expressed by baculovirus inSf9insect cells using an N-terminal His tag. MW = 74 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: His
• Description: MYLK2 is a member of the myosin light chain kinase family and is a calcium/calmodulin dependent enzyme that is exclusively expressed in adult skeletal muscle. MYLK2 has been proposed to participate in signaling pathways (calcium signaling pathway, focal adhesion, regulation of actin cytoskeleton) and cellular processes (neuromuscular synaptic transmission, protein/amino acid phosphorylation). MYLK2 is involved in multiple molecular functions as a result of various subdomains that participate in ATP binding, calmodulin binding, nucleotide binding, protein serine/threonine kinase activity and transferase activity).
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: MYLK2 myosin light chain kinase 2 [ Homo sapiens ]
• Synonyms: MYLK2; myosin light chain kinase 2; KMLC; MLCK; MLCK2; skMLCK; OTTHUMP00000030561; myosin light chain kinase 2, skeletal muscle; EC 2.7.11.18; OTTHUMP00000030560; OTTHUMP00000030562; skeletal muscle myosin light chain kinase; skeletal myosin light chain kinase; Myosin light chain kinase 2, skeletal/cardiac muscle
• Gene ID: 85366
• mRNA Refseq: NM_033118
• Protein Refseq: NP_149109
• MIM: 606566
• UniProt ID: Q9H1R3
• Chromosome Location: 20q13.31
• Pathway: Calcium signaling pathway; Focal adhesion; Regulation of actin cytoskeleton; Vascular smooth muscle contraction
• Function: ATP binding; calmodulin binding; calmodulin binding; calmodulin-dependent protein kinase activity; myosin light chain binding; myosin light chain kinase activity; myosin light chain kinase activity; nucleotide binding; transferase activity