MYLK2
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Official Full Name
myosin light chain kinase 2 -
Overview
This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. -
Synonyms
MYLK2;myosin light chain kinase 2;myosin light chain kinase 2, skeletal muscle;myosin light chain kinase 2, skeletal/cardiac muscle;KMLC;MLCK2;skeletal muscle myosin light chain kinase;skMLCK;MLCK
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Sf9 Cells
- Insect Cells
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- Sf21 Cells
- His
- GST
- His&T7
- Non
- DDK&Myc
- Avi&Fc&His
- GST&His
Involved Pathway
MYLK2 involved in several pathways and played different roles in them. We selected most pathways MYLK2 participated on our site, such as Calcium signaling pathway,Focal Adhesion,Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYLK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Focal adhesion | GRB2,PDGFD,ERBB2,TLN1,COL1A1,PRKCB,MAPK8B,FYNA,CAPN2A,COL6A2 |
| Gastric acid secretion | ATP1B3,ATP1B1,ITPR3,SSTR2,GNAI3,KCNE2,PLCB3,CAMK2D,KCNJ16,GNAQ |
| Calcium signaling pathway | CHRNA7,CALM2A,PPIFA,ADCY1A,CALM1,GNA15.1,PLCD1A,CAMK2G,NTSR1,CALML3 |
| Oxytocin signaling pathway | CACNB4,PPP1CC,CALM4,PPP3CB,PPP1CA,NOS3,GUCY1A3,KCNJ14,MAPK7,MEF2C |
| Platelet activation | ACTB,GNAS,FCGR2A,COL27A1,VASP,GP5,SRC,P2RX1,PIK3R5,PPP1CB |
| Integrin-mediated cell adhesion | SEPP1A,CAPN9,CAPN3,SEPP1,CAPNS1,CAPN11,CAPN5,CAPN10,MAPK4,CAPN3A |
| Myometrial Relaxation and Contraction Pathways | GABPB1,RGS20,RGS5,RGS10,GUCA2B,ATF5,CNN2,PKIG,RGS16,RGS18 |
Protein Function
MYLK2 has several biochemical functions, for example, ATP binding,calmodulin binding,calmodulin-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MYLK2 itself. We selected most functions MYLK2 had, and list some proteins which have the same functions with MYLK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| myosin light chain kinase activity | MYLK,MYLK3 |
| calmodulin binding | ASPM,RIT1,CAMK1,NETO2,EDF1,TRPV1,C2orf62,MYH11,RYR1,CAMK1D |
| protein binding | EBF2,KRT16,RFX4,OCA2,FAM207A,TGFBI,HSPA8,GATA1A,ZNF747,SREK1IP1 |
| calmodulin-dependent protein kinase activity | CAMK2G,CAMK4,CAMK2D1,CAMK2G1,MYLK3,NETO2,SLC14A2,PNCK,MKNK2,ITPKA |
| ATP binding | SLC22A5,DDX28,ROS1,TWF1,CAMKK1B,DDX31,PPP2R4,TTLL2,SPHK1,DDX39B |
Interacting Protein
MYLK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYLK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYLK2.
ESR1;ESR2;MEF2C;NFKB2;HSP90AB1;TNFRSF1B;TRAF2;MAP3K1;MAP3K3;HSP90AA1
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References
- Wang, HG; Dong, JN; et al. Anti-mouse CD52 monoclonal antibody ameliorates intestinal epithelial barrier function in interleukin-10 knockout mice with spontaneous chronic colitis. IMMUNOLOGY 144:254-262(2015).
- Gerarduzzi, C; He, QW; et al. Prostaglandin E-2-Dependent Blockade of Actomyosin and Stress Fibre Formation Is Mediated Through S1379 Phosphorylation of ROCK2. JOURNAL OF CELLULAR BIOCHEMISTRY 115:1516-1527(2014).
