Recombinant Human MYO18A, His-tagged

• Cat.No.: MYO18A-29759TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1628-2039 of Human MYO18A with an N terminal His tag. Predicted mwt: 48 kDa

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1628-2039 a.a.
• Description: Myo18A/Myosin XVIIIA is an unconventional myosin that contains a lysine and glutamine (KE) rich domain and a PDZ domain. The KE and PDZ domains appear to direct subcellular localization of the Myo18A variants. It is a dimeric actin binding protein that may play a role in the stabilization and organization of the actin cytoskeleton. Recently a cell surface form of Myo18A has been identified as the receptor for surfactant protein A, a lipid associated lung collectin that mediates innate and adaptive immune responses in the lungs.
• Conjugation: HIS
• Form: Lyophilised:Reconstitute with 140 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: EKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLAD AQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKA RKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQL EEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQE AKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQ RIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASR KKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIE DEMESDENEDLINSEGDSDVDSELEDRVDGVKSWLSKNKG PSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHDPLDNT SRPRYSHSYLSDSDTEAKLTETNA

Gene Information

• Gene Name: MYO18A myosin XVIIIA [ Homo sapiens ]
• Official Symbol: MYO18A
• Synonyms: MYO18A; myosin XVIIIA; myosin-XVIIIa; KIAA0216; MysPDZ
• Gene ID: 399687
• mRNA Refseq: NM_078471
• Protein Refseq: NP_510880
• MIM: 610067
• Uniprot ID: Q92614
• Chromosome Location: 17q11.2
• Function: ATP binding; DNA binding; DNA-dependent ATPase activity; motor activity; nucleotide binding