Recombinant Human MYH9, His-tagged

• Cat.No.: MYH9-29659TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1130-1960 of Human non-muscle Myosin IIA with N terminal His tag; 831 amino acids, 110kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• ProteinLength: 1130-1960 a.a.
• Description: This gene encodes a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain. The protein is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in MYH9 are the cause of non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness.
• Conjugation: HIS
• Tissue specificity: In the kidney, expressed in the glomeruli. Also expressed in leukocytes.
• Form: Lyophilised:Reconstitute with 51 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEV NILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQ TKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKR KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNV TGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQ KLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLH AQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRH EEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNL EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKAL SLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVG KSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREME AELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNR DEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEK KLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIA NSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIN DRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKE LKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNET KERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQA DKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATE TADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGS DEEVDGKADGAEAKPAE
• Sequence Similarities: Contains 1 IQ domain.Contains 1 myosin head-like domain.

Gene Information

• Gene Name: MYH9 myosin, heavy chain 9, non-muscle [ Homo sapiens ]
• Official Symbol: MYH9
• Synonyms: MYH9; myosin, heavy chain 9, non-muscle; DFNA17, myosin, heavy polypeptide 9, non muscle; myosin-9; EPSTS; FTNS; MHA; NMHC II A; NMMHCA; nonmuscle myosin heavy chain II A
• Gene ID: 4627
• mRNA Refseq: NM_002473
• Protein Refseq: NP_002464
• MIM: 160775
• Uniprot ID: P35579
• Chromosome Location: 22q13.1
• Pathway: Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Regulation of actin cytoskeleton, organism-specific biosystem; Regulation of actin cytoskeleton, conserved biosystem; Salmonella infection, organism-specific biosystem
• Function: ADP binding; ATP binding; ATP binding; ATPase activity; actin binding