MYH9
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Official Full Name
myosin, heavy chain 9, non-muscle -
Overview
This gene encodes a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain. The protein is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in MYH9 are the cause of non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. -
Synonyms
MYH9;myosin, heavy chain 9, non-muscle;DFNA17, myosin, heavy polypeptide 9, non muscle;myosin-9;EPSTS;FTNS;MHA;NMHC II A;NMMHCA;nonmuscle myosin heavy chain II A;myosin heavy chain 9;non-muscle myosin heavy chain A;non-muscle myosin heavy cha
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- GST
- His
- His&SUMO
- His&Fc&Avi
- His&Myc
Involved Pathway
MYH9 involved in several pathways and played different roles in them. We selected most pathways MYH9 participated on our site, such as Tight junction,Regulation of actin cytoskeleton,Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYH9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Salmonella infection | CCL4,MAPK11,RELA,ROCK1,ACTG1,IL18,ARPC5A,CXCL3,IL-8,IL1B |
| Tight junction | OCLNB,HRAS,CDC42L,MYH7B,MYH1C,EPB41,SHROOM2,PTENB,ACTN3A,PPP2R2A |
| Regulation of Actin Cytoskeleton | ROCK2B,LIMK2,Itgam&Itgb2,ITGA11A,INS2,ITGAM,ITGB5,ARHGEF7A,MYLK3,ACTN3 |
Protein Function
MYH9 has several biochemical functions, for example, ADP binding,ATP binding,ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MYH9 itself. We selected most functions MYH9 had, and list some proteins which have the same functions with MYH9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | TGFB1,ZFP652,GRM6,LMLN,EPHX2,PDGFA,SLIT2,TWIST1,VPS4B,UGT1A9 |
| protein domain specific binding | PLXND1,ICA1,TNFAIP1,SERPINB1A,IGBP1,PRKCI,HOMER3,NCK1,ERCC1,MYO7A |
| ATP binding | ATP2A3,DDX28,SMARCA2,YARS2,PTK2B,ITPK1,MCCC2,FLT4,WARS,TP53RK |
| ADP binding | MYO7A,MYO9B,HSP104,P2RY1,PRKAG2,MIEF1,ATP1A1,TAP1,ME1,VCP |
| contributes_to actin-dependent ATPase activity | MYH10 |
| actin-dependent ATPase activity | MYH7,MYL6,MYO1D,MYO3A,MYH10,MYO1C,MYO7A |
| microfilament motor activity | MYH7,MYH10,MYO5B,MYO3B,MYH13,MYO7A,MYO1E,MYH8,MYO1D,MYO9B |
| contributes_to actin filament binding | ACTR3,ARPC3,ACTR2,ARPC2,ARPC5,MYH10,ARPC1B,ARPC4 |
| motor activity | MYO7A,MYL6,CGNL1,MYO6B,DNAIC2,MYH7B,SMYHC1,MYHZ1.1,VMHCL,MYH6 |
Interacting Protein
MYH9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYH9 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYH9.
GRB2;MEN1;SVIL;ESR1;CXCR4
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References
- Nagatake, T; Fujita, H; et al. Enteroendocrine Cells Are Specifically Marked by Cell Surface Expression of Claudin-4 in Mouse Small Intestine. PLOS ONE 9:-(2014).
- Paul, A; Babji, S; et al. Human and bovine rotavirus strain antigens for evaluation of immunogenicity in a randomized, double-blind, placebo-controlled trial of a single dose live attenuated tetravalent, bovine-human-reassortant, oral rotavirus vaccine in Indian adults. VACCINE 32:3094-3100(2014).
