Recombinant Human MUC5AC Protein, His-tagged

• Cat.No.: MUC5AC-17H
• Product Overview: Recombinant Human MUC5AC(Tyr5568~His5654) fused with His tag at the N-terminus was produced in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300
• Molecular Mass: Predicted Molecular Mass: 16.3kDa;
  Accurate Molecular Mass: 21kDa(Analysis of differences refer to the manual)
• Protein length: Tyr5568~His5654
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: MUC5AC mucin 5AC, oligomeric mucus/gel-forming [ Homo sapiens ]
• Official Symbol: MUC5AC
• Synonyms: MUC5AC; mucin 5AC, oligomeric mucus/gel-forming; mucin 5, subtypes A and C, tracheobronchial/gastric; mucin-5AC; MUC5; gastric mucin; tracheobronchial mucin; major airway glycoprotein; lewis B blood group antigen; mucin-5 subtype AC, tracheobronchial; mucin 5AC, oligomeric mucus/gel-forming pseudogene; TBM; leB
• Gene ID: 4586
• mRNA Refseq: NM_017511
• MIM: 158373
• UniProt ID: P98088

Reviews

03/03/2022

Positive feedback from other labs and researchers confirmed its standing as a valuable research tool.

07/10/2018

The product's innovative features hinted at its potential for advancing our research in uncharted territories.

01/28/2018

Compliance with industry standards minimized potential roadblocks in securing approvals for our experiments.

Q&As

How is MUC5AC produced and where is it mainly found in the body?

MUC5AC is produced by goblet cells in the airway epithelium and is mainly found in mucus lining the respiratory tract.

In which respiratory conditions is MUC5AC expression often dysregulated or elevated?

Dysregulated or elevated expression of MUC5AC is often observed in respiratory conditions such as asthma, chronic bronchitis, and cystic fibrosis.

What is the primary role of mucin 5AC (MUC5AC) in the respiratory system?

Mucin 5AC (MUC5AC) primarily functions in the respiratory system by providing protection and lubrication to the airway epithelium.

What are the implications of abnormal MUC5AC expression in lung diseases?

Abnormal MUC5AC expression in lung diseases can contribute to mucus hypersecretion, airway obstruction, and impaired respiratory function.

Are there specific signaling pathways or molecular mechanisms associated with the regulation of MUC5AC expression?

Regulation of MUC5AC expression involves specific signaling pathways and molecular mechanisms, including the activation of transcription factors in response to inflammatory stimuli.

How does MUC5AC contribute to the defense against foreign particles and microorganisms in the respiratory tract?

MUC5AC plays a crucial role in the defense against foreign particles and microorganisms by trapping and eliminating them from the respiratory tract.

What functions does MUC5AC serve in protecting and lubricating the epithelium of the airways?

In protecting and lubricating the epithelium, MUC5AC helps prevent foreign particles and microorganisms from adhering to the airway surfaces.