Recombinant Human MTPN, His-tagged

• Cat.No.: MTPN-28770TH
• Product Overview: Recombinant full length Human Myotrophin with a N terminal His tag. 138 amino acids with a predicted MWt 15 kDa including tag.

Specification

• Description: The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3 end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease.
• Protein length: 118 amino acids
• Conjugation: HIS
• Molecular Weight: 15.000kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Ubiquitous.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:0.24% Tris, 10% Glycerol
• Storage: Please see Notes section
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD GLTAFEATDN QAIKALLQ
• Sequence Similarities: Belongs to the myotrophin family.Contains 3 ANK repeats.

Gene Information

• Gene Name: MTPN myotrophin [ Homo sapiens ]
• Official Symbol: MTPN
• Synonyms: MTPN; myotrophin; GCDP; granule cell differentiation protein; MYOTROPHIN; V 1
• Gene ID: 136319
• mRNA Refseq: NM_145808
• Protein Refseq: NP_665807
• MIM: 606484
• Uniprot ID: P58546
• Chromosome Location: 7q33-q35