Recombinant Human MSR1 Protein, GST-His-tagged
| Cat.No. : | MSR1-743H |
| Product Overview : | Recombinant Human MSR1, transcript variant SR-AI, fused with N-terminal GST and C-terminal His was expressed in E. coli. |
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| Description : | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. |
| Source : | E. coli |
| Species : | Human |
| Tag : | His&GST |
| Form : | 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1%Sarkosyl. |
| Molecular Mass : | 75.6 kDa |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration : | >50 ug/mL as determined by microplate BCA method |
| Gene Name | MSR1 macrophage scavenger receptor 1 [ Homo sapiens ] |
| Official Symbol | MSR1 |
| Synonyms | MSR1; macrophage scavenger receptor 1; macrophage scavenger receptor types I and II; CD204; SCARA1; scavenger receptor class A member 1; scavenger receptor class A, member 1; macrophage scavenger receptor type III; macrophage acetylated LDL receptor I and II; SRA; SR-A; phSR1; phSR2; |
| Gene ID | 4481 |
| mRNA Refseq | NM_138716 |
| Protein Refseq | NP_619730 |
| MIM | 153622 |
| UniProt ID | P21757 |
Not For Human Consumption!
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