Recombinant Human monoamine oxidase B,His-tagged

• Cat.No.: MAOB-107H
• Product Overview: Recombinant Human MAO-B comprises a 488 amino acid fragment (2-489) corresponding to the cytoplasmic domain fragment of the mature MAO-B protein and is expressed in E. coli with an amino-terminal hexahistidine tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 2-489 a.a.
• Description: Monoamine oxidase B (MAO-B) is a flavin-containing mitochondrial enzyme, which catalyzes the oxidative deamination of biogenic and xenobiotic monoamines. It regulates the metabolic degradation of catecholamines and serotonin in neural and other target tissues. MAO-B is found platelets and in dopamine-secreting neurons in the brain. Increased levels of MAO B that have been identified in brain of Alzheimer's patients. Monoamine oxidases (MAO B and MAO A) are well-known targets for antidepressant drugs and for drugs used to treat neurological disorders and aging diseases, such as Parkinson's and Alzheimer's disease.
• Purity: >95% by SDS-PAGE
• Form: Liquid
• Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.

Gene Information

• Gene Name: MAOB monoamine oxidase B [ Homo sapiens ]
• Synonyms: MAOB; MGC26382; monoamine oxidase B; MAO, brain; MAO, platelet; tyramine oxidase; adrenalin oxidase; EC 1.4.3.4; MAO-B.
• Gene ID: 4129
• mRNA Refseq: NM_000898
• Protein Refseq: NP_000889
• MIM: 309860
• UniProt ID: P27338.3
• Chromosome Location: Xp11.23
• Pathway: Glycine, serine and threonine metabolism; Histidine metabolism; Phenylalanine metabolism; Tryptophan metabolism; Tyrosine metabolism; Urea cycle and metabolism of amino groups; Biological oxidations
• Function: amine oxidase activity; electron carrier activity; oxidoreductase activity