Active Recombinant Human MLL2 protein, GST-tagged
Cat.No. : | MLL2-190H |
Product Overview : | Recombinant Human MLL2(5317-end) fused with GST tag at N-terminal was expressed in Insect cells. |
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Species : | Human |
Source : | Insect Cells |
Tag : | GST |
Protein Length : | 5317-end |
Description : | Histone-lysine N-methyltransferase 2D, also known as mixed-lineage leukemia 2 (MLL2), methylates 'Lys-4' of histone H3 (H3K4me). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. MLL2/KMT2D is among the most frequently mutated genes in a variety of pediatric tumors. |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 2.5 nmol/min/mg |
Molecular Mass : | 51 kDa |
Purity : | >80% |
Applications : | Methyltransferase Assay |
Stability : | 1 year at -70 centigrade from the date of shipment |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name | MLL2 myeloid/lymphoid or mixed-lineage leukemia 2 [ Homo sapiens ] |
Official Symbol | MLL2 |
Synonyms | MLL2; myeloid/lymphoid or mixed-lineage leukemia 2; TNRC21, trinucleotide repeat containing 21; histone-lysine N-methyltransferase MLL2; ALR; CAGL114; KMT2D; MLL4; ALL1-related protein; Kabuki make-up syndrome; lysine N-methyltransferase 2B; lysine N-meth |
Gene ID | 8085 |
mRNA Refseq | NM_003482 |
Protein Refseq | NP_003473 |
MIM | 602113 |
UniProt ID | O14686 |
Chromosome Location | 12q13.12 |
Pathway | Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; |
Function | DNA binding; histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; protein binding; transcription regulatory region DNA binding; transferase activity; zinc ion binding; |
◆ Recombinant Proteins | ||
MLL2-190H | Active Recombinant Human MLL2 protein, GST-tagged | +Inquiry |
Not For Human Consumption!
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