MLL2
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Official Full Name
myeloid/lymphoid or mixed-lineage leukemia 2 -
Overview
The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. -
Synonyms
MLL2;myeloid/lymphoid or mixed-lineage leukemia 2;TNRC21, trinucleotide repeat containing 21;histone-lysine N-methyltransferase MLL2;ALR;CAGL114;KMT2D;MLL4;ALL1 related gene;Myeloid/lymphoid or mixed lineage leukemia 2;ALL1-related protein;Kabuki make-up syndrome;lysine N-methyltransferase 2B;lysine N-methyltransferase 2D;Kabuki mental retardation syndrome;trinucleotide repeat containing 21;KMS;AAD10;KMT2B;TNRC21
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MLL2-190H |
Active Recombinant Human MLL2 protein, GST-tagged
|
Insect Cells | Human | GST | 5317-end |
|
Involved Pathway
MLL2 involved in several pathways and played different roles in them. We selected most pathways MLL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MLL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MLL2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MLL2 itself. We selected most functions MLL2 had, and list some proteins which have the same functions with MLL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
MLL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MLL2.
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References
- LOSMAN, MJ; LEUNG, SO; et al. DEVELOPMENT AND EVALUATION OF THE SPECIFICITY OF A RAT MONOCLONAL ANTIIDIOTYPE ANTIBODY, WN, TO AN ANTI-B-CELL LYMPHOMA MONOCLONAL-ANTIBODY, LL2. CANCER RESEARCH 55:S5978-S5982(1995).
- Leung, SO; Goldenberg, DM; et al. Construction and characterization of a humanized, internalizing, B-cell (CD22)-specific, leukemia/lymphoma antibody, LL2. MOLECULAR IMMUNOLOGY 32:1413-1427(1995).
- LEUNG, SO; SHEVITZ, J; et al. CHIMERIZATION OF LL2, A RAPIDLY INTERNALIZING ANTIBODY SPECIFIC FOR B-CELL LYMPHOMA. HYBRIDOMA 13:469-476(1994).
