Recombinant Human MKNK2 Protein (T72-R385), Tag Free
Cat.No. : | MKNK2-1164H |
Product Overview : | Recombinant Human MKNK2(T72-R385) Protein was expressed in E. coli. |
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Species : | Human |
Source : | E.coli |
Tag : | Non |
Protein Length : | T72-R385 |
Description : | Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. |
Form : | Liquid |
Endotoxin : | < 0.01 EU per μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol |
Shipping : | It is shipped out with blue ice. |
Gene Name | MKNK2 MAP kinase interacting serine/threonine kinase 2 [ Homo sapiens (human) ] |
Official Symbol | MKNK2 |
Synonyms | MKNK2; MAP kinase interacting serine/threonine kinase 2; G protein coupled receptor kinase 7, GPRK7; MAP kinase-interacting serine/threonine-protein kinase 2; MNK2; Putative map kinase interacting kinase; MAPK signal-integrating kinase 2; G protein-coupled receptor kinase 7; MAP kinase signal-integrating kinase 2; GPRK7; |
Gene ID | 2872 |
mRNA Refseq | NM_017572 |
Protein Refseq | NP_060042 |
MIM | 605069 |
UniProt ID | Q9HBH9 |
◆ Recombinant Proteins | ||
MKNK2-37H | Recombinant Human MKNK2 Protein(72-385), His tagged | +Inquiry |
MKNK2-5368H | Active Recombinant Human MKNK2 Protein, GST-tagged | +Inquiry |
MKNK2-1164H | Recombinant Human MKNK2 Protein (T72-R385), Tag Free | +Inquiry |
MKNK2-5369H | Recombinant Human MKNK2 Protein, GST-tagged | +Inquiry |
Mknk2-4084M | Recombinant Mouse Mknk2 Protein, Myc/DDK-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
MKNK2-4301HCL | Recombinant Human MKNK2 293 Cell Lysate | +Inquiry |
MKNK2-4302HCL | Recombinant Human MKNK2 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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