MKNK2
-
Official Full Name
MAP kinase interacting serine/threonine kinase 2 -
Overview
This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. -
Synonyms
MKNK2;MAP kinase interacting serine/threonine kinase 2;G protein coupled receptor kinase 7 , GPRK7;MAP kinase-interacting serine/threonine-protein kinase 2;MNK2;Putative map kinase interacting kinase;MAP kinase signal integrating kinase 2;G protein coupled receptor kinase 7;GPRK7;MAP kinase interacting serine threonine kinase 2;MAP kinase interacting serine threonine kinase;MAP kinase interacting serine threonine protein kinase 2;MAP kinase signal-integrating kinase 2;MAPK interacting kinase 2;Mitogen activated protein kinase interacting serine threonine kinase 2;MKNK2_HUMAN;G protein-coupled receptor kinase 7
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Sf9 Cells
- Mammalian Cells
- HEK293
- Insect Cells
- Wheat Germ
- In Vitro Cell Free System
- Sf21 Cells
- His
- Non
- GST
- Flag
- Avi&Fc&His
- DDK&Myc
Involved Pathway
MKNK2 involved in several pathways and played different roles in them. We selected most pathways MKNK2 participated on our site, such as MAPK signaling pathway,HIF- signaling pathway,Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MKNK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIF- signaling pathway | EP300,PLCG2,HK2,TLR4,PRKCB,ENO3,ERBB2,HK1,INS1,CAMK2G |
| Insulin signaling pathway | LIPE,MAP2K1,EIF4E2RS1,MAP2K2B,PRKCZ,PPP1CAB,PCK1,PPP1CC,PRKAR2B,PPP1R3DA |
| MAPK signaling pathway | FOS,NLK,MAPK8IP2,HSP70L,HSP70,PDGFAA,TAB2,TGFB3,RAP1AA,RASGRF2 |
Protein Function
MKNK2 has several biochemical functions, for example, ATP binding,calcium-dependent protein serine/threonine kinase activity,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MKNK2 itself. We selected most functions MKNK2 had, and list some proteins which have the same functions with MKNK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | MYO1D,ATPIF1,ATP2B4,CAMK2D2,MYO10,PDE1C,TRPV4,PLCB3,MARCKSA,VAMP2 |
| protein serine/threonine kinase activity | CSNK1G2,PIM2,PRKD2,GAK,MAPK1,CDC7,SLKA,PLK4,BMPR1BA,BSK146 |
| ATP binding | ATP2C1,DNAH11,P2RY1,XRCC3,PKZ,ACSM4,DNAH5,CMPK1,SGK2B,TRMU |
| calcium-dependent protein serine/threonine kinase activity | MAPKAPK2,MAPKAPK5,CAMK4,MKNK2B,CAMK1GB,DCX,MKNK2A,CAMK1GA,MAPKAPK2A,MKNK1 |
| calmodulin-dependent protein kinase activity | SLC14A2,PNCK,MYLK2,CAMK1G,CAMK2G1,MAPKAPK2B,MKNK2A,CAMKK2,CAMK2A,CAMK1GB |
| protein binding | GTF2H4,HELLS,PEPD,NDUFA4,PIKFYVE,IRF8,AASDHPPT,HDGF2,ACTB,FKBP5 |
| metal ion binding | ZFP12,ZNF319,ZNF404,DGKAA,UQCRC2B,TCN2,RNF145B,CH25HL2,DTD1,MUS81 |
Interacting Protein
MKNK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MKNK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MKNK2.
MAPK14;LRRK2;SRPK1;MAPK8;RPL7A;syd;WWP2;WDR46;NUDT21;EXOC3;MIF;VCL;CSTF2;BAG6;PLXNA3;TRAP1;NOLC1
Resources
Related Services
Related Products
References
- Neto, LRP; Jonsson, NN; et al. The RIPK2 gene: a positional candidate for tick burden supported by genetic associations in cattle and immunological response of knockout mouse. IMMUNOGENETICS 64:379-388(2012).
- Dorsch, M; Wang, AL; et al. Identification of a regulatory autophosphorylation site in the serine-threonine kinase RIP2. CELLULAR SIGNALLING 18:2223-2229(2006).
