Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2, His-tagged
| Cat.No. : | MAP4K2-1263H |
| Product Overview : | Recombinant human full length MAP4K2,His-tagged is expressed in Insect cells. |
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| Cat. No. : | MAP4K2-1263H | ||
| Description : | MAP4K2 is an enzymethat in humans is encoded by the MAP4K2 gene. The protein encoded by thisgene is a member of the serine/threonine protein kinase family. Although thiskinase is found in many tissues, its expression in lymphoid follicles isrestricted to the cells of germinal centre, where it may participate inB-cell differentiation. This kinase can be activated by TNF-alpha, and hasbeen shown to specifically activate MAP kinases. This kinase is also found tointeract with TNF receptor-associated factor 2 (TRAF2), which is involved inthe activation of MAP3K1/MEKK1. | ||
| Source : | Insect cells | ||
| Species : | Human | ||
| Form : | Liquid in50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mMDTT + 50% glycerol. | ||
| Molecular Weight : | 95.6 kDa | ||
| Concentration : | 0.42mg/ml | ||
| Specific Activity : | 728 nmole of phosphate transferred tomyelin basic protein (MBP) per minute per mg of total protein at 30°C.Activity determined at a final protein concentration of 3.33 μg/ml. | ||
| Storage : | Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles. | ||
| OfficialSymbol : | MAP4K2 | ||
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| Full Length : | Full L. |
| Gene Name | MAP4K2 mitogen-activated protein kinase kinase kinase kinase2 [ Homo sapiens ] |
| Synonyms | MAP4K2; mitogen-activated protein kinasekinase kinase kinase 2; RAB8IP; BL44; GCK; OTTHUMP00000042793; OTTHUMP00000069727;OTTHUMP00000069728; OTTHUMP00000199616; OTTHUMP00000199613; OTTHUMP00000199614;OTTHUMP00000199615; EC 2.7.11.1; B lymphocyte serine/threonine-protein kinase;Germinal center kinase; GC kinase; MAPK/ERK kinase kinase 2; MEK kinasekinase 2; MEKKK2; Rab8-interacting protein; B lymphocyte serine/threonine proteinkinase; germinal centre kinase (GC kinase); EC 2.7.11; Rab8 interactingprotein; Germinal centre kinase |
| Gene ID | 5871 |
| mRNA Refseq | NM_004579 |
| Protein Refseq | NP_004570 |
| MIM | 603166 |
| UniProt ID | Q12851 |
| Chromosome Location | 11q13.1 |
| Pathway | MAPK signalingpathway; InsulinSignaling; TNF receptor signaling pathway |
Not For Human Consumption!
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