Recombinant Human MAP4K2

• Cat.No.: MAP4K2-28743TH
• Product Overview: Recombinant full length Human Germinal Center Kinase with N-terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system; amino acids 1-820, 125kDa.

Specification

• Description: The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.
• Biological activity: The Specific activity of MAP4K2-28743TH was determined to be 290 nmol/min/mg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Tag: Non
• Protein length: 1-820 a.a.
• Full Length: Full L.

Gene Information

• Gene Name: MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 [ Homo sapiens ]
• Official Symbol: MAP4K2
• Synonyms: MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2; RAB8IP; BL44; GCK
• Gene ID: 5871
• mRNA Refseq: NM_004579
• Protein Refseq: NP_004570
• MIM: 603166
• Uniprot ID: Q12851
• Chromosome Location: 11q13.1
• Pathway: Insulin Signaling, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem; TNF receptor signaling pathway, organism-specific biosystem
• Function: ATP binding; ATP binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding