Recombinant Human Mitogen-activated Protein Kinase 11

• Cat.No.: MAPK11-734H
• Product Overview: Recombinant Human p38-beta, full length, amino acids M1-Q364, activated, untagged, was expressed inE. coli.MW = 41,485 Da.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 38-b a.a.
• Description: P38β is a member of the p38 MAP kinase family and is activated by both proinflammatory cytokines and environmental stress. The p38β is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. Alternatively spliced transcript variants encoding the same protein have been observed.
• Purification: Immobilized Metal Affinity Chromatography.
• Product Identity: p38-beta was confirmed as p38-beta by mass spectroscopy LCESI-MS/MS (Protagen AG, Germany).
• Activation: With MKK6 SDTD (GenBank accession No.: NM_002758.2).
• Storage Buffer: 50 mM HEPES pH 7.5, 100 mM NaCl, 3 mM βME, 20% glycerol.
• Concentration: 0.810 μg/μl (Bradford method using BSA [Sigma, cat# A-7638, Lot 79H7641] as standard protein).
• Specific Activity: 701 pmol/μg×min.
• Storage: -80°C. Avoid repeated freeze-thaw cycles!
• Full Length: Full L.

Gene Information

• Gene Name: MAPK11 mitogen-activated protein kinase 11 [ Homo sapiens ]
• Synonyms: MAPK11; mitogen-activated protein kinase 11; P38B; SAPK2; p38-2; PRKM11; SAPK2B; p38Beta; P38BETA2; OTTHUMP00000196655; stress-activated protein kinase-2; stress-activated protein kinase-2b; mitogen-activated protein kinase p38-2; mitogen-activated protein kinase p38 beta; EC 2.7.11.24
• Gene ID: 5600
• mRNA Refseq: NM_002751
• Protein Refseq: NP_002742
• MIM: 602898
• UniProt ID: Q15759
• Chromosome Location: 22q13.33
• Pathway: Amyotrophic lateral sclerosis (ALS); Epithelial cell signaling in Helicobacter pylori infection; Fc epsilon RI signaling pathway; GnRH signaling pathway; Leukocyte transendothelial migration; MAPK signaling pathway; Neurotrophin signaling pathway; RIG-I-like receptor signaling pathway; T cell receptor signaling pathway; Toll-like receptor signaling pathway; VEGF signaling pathway; Signalling by NGF
• Function: ATP binding; MAP kinase activity; MAP kinase kinase activity; MP kinase activity; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein serine/threonine kinase activity; transferase activity