Recombinant Human Mitogen-activated Protein Kinase 10

• Cat.No.: MAPK10-752H
• Product Overview: Recombinant Human Human Mitogen-activated Protein Kinase 10 Amino acidsM1-R428, is expressed inE.coli.

Specification

• Cat. No.: MAPK10-752H
• Description: JNK3 is a member of the c-Jun N-terminal kinases (JNKs) which are part of the mitogen-activated protein (MAP) kinase family, and regulate signal transduction in response to environmental stress. JNK3 phosphorylates various transcription factors such as ATF2, Elk-1 and members of the Jun family. Activation and nuclear localization of JNK3, a neuronal-specific isoform of JNK, has been associated with hypoxic and ischemic damage of CA1 neurons in the hippocampus.
• Source: E.coli.
• Purification: Immobilized Metal Affinity Chromatography.
• Product Identity: JNK3 was confirmed as JNK3 by mass spectroscopy LC-ESI-MS/MS.
• MW: 48,060 Da.
• Storage Buffer: 50 mM Tris-HCl, pH 7.5; 100 mM NaCl, 5 mM DTT, 20% glycerol.
• Concentration: 0.211 μg/μl.
• Specific Activity: 118 pmol/μg×min.
• Storage: -80°C. Avoid repeated freeze-thaw cycles!
• Tag: Non
• Protein length: 1-428 a.a.

Gene Information

• Gene Name: MAPK10 mitogen-activated protein kinase 10 [ Homo sapiens ]
• Synonyms:
  MAPK10; mitogen-activated protein kinase 10; JNK3; JNK3A; PRKM10; p493F12; FLJ12099; FLJ33785; MGC50974; p54bSAPK; MAP kinase; OTTHUMP00000161180; OTTHUMP00000161183; JNK3 alpha protein kinase; c-Jun N-terminal kinase 3; stress activated protein kinase beta; EC 2.7.11.24; MAP kinase p49 3F12; OTTHUMP00000161182; c-Jun kinase 3
• Gene ID: 5602
• mRNA Refseq: NM_002753
• Protein Refseq: NP_002744
• MIM: 602897
• UniProt ID: P53779
• Chromosome Location: 4q22.1-q23
• Pathway: Adipocytokine signaling pathway; Colorectal cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Focal adhesion; GnRH signaling pathway; Insulin signaling pathway; MAPK signaling pathway; NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Pancreatic cancer; Pathways in cancer; Progesterone-mediated oocyte maturation; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway; Type II diabetes mellitus; Wnt signaling pathway
• Function: ATP binding; JUN kinase activity; MAP kinase activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity