Recombinant Human MGMT, His-tagged
Cat.No. : | MGMT-6958H |
Product Overview : | Recombinant full length human MGMT was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. |
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Species : | Human |
Source : | Sf9 Cells |
Tag : | His |
Protein Length : | Full length |
Description : | MGMT or O-6-methylguanine-DNA methyltransferase is the major mutagenic and carcinogenic lesion in DNA induced by simple alkylating mutagens. The methylation of the MGMT promoter in gliomas is a useful predictor of the responsiveness of the tumors to alkylating agents. The clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide. Methylation of the MGMT promoter in tumors is associated with longer survival in glioblastoma patients. |
Form : | Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Molecular Mass : | ~25 kDa |
Purity : | >95% |
Applications : | Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.1 μg/μ |
Gene Name | MGMT O-6-methylguanine-DNA methyltransferase [ Homo sapiens ] |
Official Symbol | MGMT |
Synonyms | MGMT; O-6-methylguanine-DNA methyltransferase; methylated-DNA--protein-cysteine methyltransferase; methylguanine-DNA methyltransferase; O-6-methylguanine-DNA-alkyltransferase; O6-methylguanine-DNA methyltransferase; 6-O-methylguanine-DNA methyltransferase; |
Gene ID | 4255 |
mRNA Refseq | NM_002412 |
Protein Refseq | NP_002403 |
MIM | 156569 |
UniProt ID | P16455 |
Chromosome Location | 10q26 |
Pathway | DNA Damage Reversal, organism-specific biosystem; DNA Repair, organism-specific biosystem; |
Function | DNA binding; DNA-methyltransferase activity; calcium ion binding; methylated-DNA-[protein]-cysteine S-methyltransferase activity; methyltransferase activity; transferase activity; |
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Not For Human Consumption!
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