Recombinant Human MGEA5, MYC/DDK-tagged

• Cat.No.: MGEA5-86H
• Product Overview: Recombinant Human MGEA5, transcript variant 1, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: Myc&DDK
• Description: The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications.
• Molecular Mass: 102.7 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: MGEA5 meningioma expressed antigen 5 (hyaluronidase) [ Homo sapiens (human) ]
• Official Symbol: MGEA5
• Synonyms: MGEA5; meningioma expressed antigen 5 (hyaluronidase); bifunctional protein NCOAT; MEA5; NCOAT; nuclear cytoplasmic O GlcNAcase and acetyltransferase; OGA; O-GlcNAcase; hyaluronidase in meningioma; meningioma-expressed antigen 5; nuclear cytoplasmic O-GlcNAcase and acetyltransferase; FLJ11229; FLJ23355; KIAA0679
• Gene ID: 10724
• mRNA Refseq: NM_012215
• Protein Refseq: NP_036347
• MIM: 604039
• UniProt ID: O60502
• Chromosome Location: 10q24.1-q24.3
• Pathway: protein O-[N-acetyl]-glucosylation
• Function: beta-N-acetylglucosaminidase activity; histone acetyltransferase activity; hyalurononglucosaminidase activity