MGEA5
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Official Full Name
meningioma expressed antigen 5 (hyaluronidase) -
Overview
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and;removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a;glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 (PubMed 11148210)). -
Synonyms
MGEA5;meningioma expressed antigen 5 (hyaluronidase);bifunctional protein NCOAT;MEA5;NCOAT;nuclear cytoplasmic O GlcNAcase and acetyltransferase;OGA;Glycoside hydrolase O-GlcNAcase;HAT;HEXC;Hexosaminidase C;Histone acetyltransferase;KIAA0679;Meningioma expressed antigen 5;Meningioma-expressed antigen 5;MGEA 5;N-acetyl-beta-D-glucosaminidase;N-acetyl-beta-glucosaminidase;NCOAT_HUMAN;Nuclear cytoplasmic O-GlcNAcase and acetyltransferase;O-GlcNAcase;hyaluronidase in meningioma
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Myc&DDK
- Non
- His&Fc&Avi
- GST
- Flag
Involved Pathway
MGEA5 involved in several pathways and played different roles in them. We selected most pathways MGEA5 participated on our site, such as Insulin resistance,protein O-[N-acetyl]-glucosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGEA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin resistance | FOXO1A,GYS2,AKT3A,NFKB1,PIK3R5,PPARA,PIK3R3B,PTEN,PPP1CA,PIK3R2 |
Protein Function
MGEA5 has several biochemical functions, for example, beta-N-acetylglucosaminidase activity,histone acetyltransferase activity,hyalurononglucosaminidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MGEA5 itself. We selected most functions MGEA5 had, and list some proteins which have the same functions with MGEA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone acetyltransferase activity | CLOCK,KAT6A,KAT6B,KAT8,HTATIP,METTL8,NCOA1,KAT7A,NCOA2,CSRP2BP |
| hyalurononglucosaminidase activity | KIAA1199,CD44,HYAL2,HYAL3,HYAL4,HYAL1,HYAL6,SPAM1 |
Interacting Protein
MGEA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGEA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MGEA5.
MDM2;FKBP5;NUDCD3;q96be0_human;CYLD;A2M;GSK3B;HAP1;CSNK2B;CDC37;q5nhh0_fratt;phhA;dAK1_1;SPAG5;RNF32;MAST1;CBX8
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