Recombinant Human METTL3 and METTL14 Protein, His/GST/His-tagged

• Cat.No.: METTL3-166H
• Product Overview: Recombinant human N-terminal histidine-tagged METTL3 and recombinant human N-terminal GST-histidine-tagged METTL14 expressed in insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST&His
• Protein Length: 2-580 and 2-456 for METTL3 and METTL14, respectively
• Description: This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
• Molecular Mass: 66.3 and 79.1 kDa for METTL3 and METTL14, respectively
• Purity: ≥80% estimated by SDS-PAGE
• Stability: ≥ 6 months
• Storage: At -80 centigrade.
• Storage Buffer: 10 mM Tris, with 500 mM sodium chloride, 1 mM DTT, and 5% glycerol

Gene Information

• Gene Name: METTL3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit [ Homo sapiens (human) ]
• Official Symbol: METTL3
• Synonyms: METTL3; methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit; M6A; IME4; Spo8; MT-A70; hMETTL3; N6-adenosine-methyltransferase catalytic subunit; N6-adenosine-methyltransferase 70 kDa subunit; adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase; mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; mRNA m(6)A methyltransferase; methyltransferase like 3; methyltransferase-like protein 3; EC 2.1.1.348
• Gene ID: 56339
• mRNA Refseq: NM_019852
• Protein Refseq: NP_062826
• MIM: 612472
• UniProt ID: Q86U44