Recombinant Human MCM7

• Cat.No.: MCM7-28043TH
• Product Overview: Recombinant full length Human MCM7 with N terminal proprietary tag; Predicted MWt 68.90 kDa.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 389 amino acids
• Description: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Molecular Weight: 68.900kDa inclusive of tags
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRL AHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADA VQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVR SPQNQYPAELMRRFELYFQGPSSSKPRVIREVRADSVGKL VTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTF MPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEH SDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPI LRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELT REELRQIADVIFATVRELVSGGRSVRFSEAEQRCVSRGFT PAQFQAALDEYEELNVWQVNASRTRITFV
• Sequence Similarities: Belongs to the MCM family.Contains 1 MCM domain.

Gene Information

• Gene Name: MCM7 minichromosome maintenance complex component 7 [ Homo sapiens ]
• Official Symbol: MCM7
• Synonyms: MCM7; minichromosome maintenance complex component 7; MCM2, MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) , minichromosome maintenance deficient (S. cerevisiae) 7; DNA replication licensing factor MCM7; CDC47
• Gene ID: 4176
• mRNA Refseq: NM_005916
• Protein Refseq: NP_005907
• MIM: 600592
• Uniprot ID: P33993
• Chromosome Location: 7q21.3-q22.1
• Pathway: Activation of ATR in response to replication stress, organism-specific biosystem; Activation of the pre-replicative complex, organism-specific biosystem; Assembly of the pre-replicative complex, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem
• Function: ATP binding; contributes_to ATP-dependent DNA helicase activity; contributes_to DNA binding; hydrolase activity; nucleotide binding