Recombinant Human MBD4 Protein, His-tagged

• Cat.No.: MBD4-333H
• Product Overview: Active Full length Recombinant Human MBD4 (Methyl-CpG Binding Domain Protein 4) Protein is produced in SF9 Insect Cells and is fused with a His tag at the N-terminal.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Description: MBD4 (UniProt/Swiss-Prot entry O95243) belongs to the family of methyl CpG binding proteins that specifically bind to methylated CpG dinucleotides. MBD4 probably functions to mediate the biological consequences of CpG methylation. Further, MBD4 has thymine glycosylase activity and is involved in DNA mismatch repair. It is specific for G/T mismatches within methylated and unmethylated CpG sites Mutations of MBD4 are associated with tumors with primary microsatellite-instability, a type of genomic instability that is caused by a defective DNA mismatch repair.
• Form: 20mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 M NaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT.
• Purity: Purified using FPLC, >95% purity as determined by SDS-PAGE.
• Notes: This product is for research use only. Not for use in diagnostic or therapeutic procedures.
• Stability: Guaranteed stable for 2 years from date of receipt when stored properly.
• Storage: Store at -80 centigrade.
• Concentration: 0.5 µg/µl
• Full Length: Full L.

Gene Information

• Gene Name: MBD4 methyl-CpG binding domain protein 4 [ Homo sapiens ]
• Official Symbol: MBD4
• Synonyms: MBD4; methyl-CpG binding domain protein 4; MED1; G/T mismatch glycosylase; G/U mismatch glycosylase
• Gene ID: 8930
• mRNA Refseq: NM_003925
• Protein Refseq: NP_003916
• MIM: 603574
• UniProt ID: O95243