Recombinant Human MATK Protein, GST-tagged

• Cat.No.: MATK-50H
• Product Overview: Full-length recombinant human MATK (CTK) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Insect cells
• Tag: GST
• Description: MATK belongs to tyrosine protein kinase family, CSK subfamily. It inactivates Src family kinase activity by specifically phosphorylating their C-terminal regulatory tyrosine residue and may plays a significant role in the signal transduction of hematopoietic cells. MATK binds to the phosphorylated Tyr568/570 sites on c-KIT to which FYN binds and leads to the down-regulation of FYN. MATK has been shown to be involved in signaling in some cases of breast cancer.
• Molecular Mass: ~83 kDa
• Applications: KA, WB
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Storage Buffer: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Gene Information

• Gene Name: MATK megakaryocyte-associated tyrosine kinase [ Homo sapiens (human) ]
• Official Symbol: MATK megakaryocyte-associated tyrosine kinase [ Homo sapiens (human) ]
• Synonyms: CHK; CTK; HHYLTK; HYL; HYLTK; LSK; MATK; megakaryocyte-associated tyrosine kinase; megakaryocyte-associated tyrosine-protein kinase; CSK homologous kinase; Csk-homologous kinase; Csk-type protein tyrosine kinase; HYL tyrosine kinase; hematopoietic consensus tyrosine-lacking kinase; hydroxyaryl-protein kinase; leukocyte carboxyl-terminal src kinase related; protein kinase HYL; tyrosine kinase MATK; tyrosine-protein kinase CTK; tyrosylprotein kinase; EC 2.7.10.2
• Gene ID: 4145
• mRNA Refseq: NM_002378
• Protein Refseq: NP_002369
• MIM: 600038
• UniProt ID: P42679