MATK

  • Official Full Name

    megakaryocyte-associated tyrosine kinase

  • Overview

    The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.

  • Synonyms

    MATK;megakaryocyte-associated tyrosine kinase;megakaryocyte-associated tyrosine-protein kinase;CHK;Csk homologous kinase;Csk type protein tyrosine kinase;CTK;DKFZp434N1212;hematopoietic consensus tyrosine lacking kinase;HHYLTK;hydroxyaryl protein kinase;HYL;HYL tyrosine kinase;HYLTK;leukocyte carboxyl terminal src kinase relat;EC 2.7.10.2;Leukocyte carboxyl terminal src kinase related;Lsk;Megakaryocyte associated tyrosine kinase;Megakaryocyte associated tyrosine protein kinase;MGC1708;MGC2101;Protein kinase HYL;Tyrosine kinase MATK;Tyrosine protein kinase CTK;Tyrosylprotein kinase;Csk-homologous kinase;hydroxyaryl-protein kinase;tyrosine-protein kinase CTK;Csk-type protein tyrosine kinase;leukocyte carb

Recombinant Proteins

  • Rat
  • Human
  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • Insect cells
  • His
  • His&T7
  • Non
  • GST&His
  • Avi&Fc&His
  • DDK&Myc
  • GST

    Involved Pathway

    MATK involved in several pathways and played different roles in them. We selected most pathways MATK participated on our site, such as Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MATK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neurotrophin signaling pathway ATF4,NTRK2,RHOA,NTRK3,RAC1,PIK3R5,ABL1,RAP1B,CAMK2A,SORT1

    Protein Function

    MATK has several biochemical functions, for example, ATP binding,non-membrane spanning protein tyrosine kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MATK itself. We selected most functions MATK had, and list some proteins which have the same functions with MATK. You can find most of the proteins on our site.

    Function Related Protein
    non-membrane spanning protein tyrosine kinase activity FES,PTK2BB,BTK,PTK2AA,TNK2,JAK2B,SYK,MELK,PTK2AB,TNK2B
    ATP binding PRKD1,TAF1,DNAJA2,SGK2A,ACVR1,MKNK2B,BCS1L,KIF27,MYH8,SPHK1
    protein binding DNAJA1,MED29,OLFM2,C12orf50,CD84,TMED5,DDC,RPSA,HIST1H1A,GPC3
    protein tyrosine kinase activity HCK,FES,ZAP70,TESK2,TESK1,EPHB4A,SRC,PDGFRB,ABL1,EPHB3A
    receptor binding TDGF1,ANKRD13C,GRP,SELPLG,CTNND1,HAO2,CADM1B,DDX54,HAND2,NTF7

    Interacting Protein

    MATK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MATK here. Most of them are supplied by our site. Hope this information will be useful for your research of MATK.

    LRRK2;ERBB2;HSP90AB1;FRS3;PTK2B;MET;AR;LRRK1;CDC37;CACNA1A;EWSR1

    Resources

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