Recombinant Human MAPT Protein (216-391), N-AVI-tagged, Biotinylated

• Cat.No.: MAPT-39H
• Product Overview: Recombinant human Tau-441 (216-391) was expressed in E. coli cells with an N-terminal Avi tag and biotinylated in vitro prior to the final chromatography purification.

Specification

• Description: Tau-441 or Tau-F is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules. Deposits of Alzheimer's disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, myloid precursor protein, ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system.
• Source: E.coli
• Species: Human
• Tag: Avi
• Molecular Mass: Observed MW: ~24 kDa.
  Calculated MW: ~20 kDa.
• Protein length: 216-391
• Purity: The purity of Tau-441 (216-391) was determined to be > 85 % by densitometry.
• Stability: One year at -70 centigrade from date of shipment.
• Storage: Store product at -70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.2 μg/μL
• Storage Buffer: Recombinant protein stored in the buffer: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 25% glycerol.
• Shipping: Dry ice

Gene Information

• Gene Name: MAPT microtubule associated protein tau [ Homo sapiens (human) ]
• Official Symbol: MAPT
• Synonyms: MAPT; microtubule associated protein tau; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; tau-40; FTDP-17; PPP1R103; Tau-PHF6
• Gene ID: 4137
• mRNA Refseq: NM_016841
• Protein Refseq: NP_058525
• MIM: 157140
• UniProt ID: P10636