Recombinant Human microtubule-associated protein tau Protein, Tag Free, Biotin Labeled

• Cat.No.: MAPT-50H
• Product Overview: The recombinant human Tau (Tau-441) (GenBank Accession # AAC04279.1) was expressed and purified from E. coli and conjugated with biotin.

Specification

• Description: This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
• Source: E. coli
• Species: Human
• Tag: Non
• Protein length: 1-758aa
• Conjugation/Label: Biotin
• Form: Solution
• Molecular Mass: 71.8 kDa (higher apparent mass in SDS-PAGE)
• Usage: Research use
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 1 mg/mL
• Storage Buffer: 10 mM sodium phosphate buffer (pH=7.4)
• References: 1. Bulic B., Neuropharmacology. 59 (2010):276-89.
  2. Voss K., Mol. Neurodegen. 4 (2009):1-12.
  3. Rankin CA., Mol. Neurodegen. 2 (2007):1-14.
  4. Patterson KR., J. of Biol. Chem. 286 (2011):23063-76.

Gene Information

• Gene Name: MAPT microtubule-associated protein tau [ Homo sapiens (human) ]
• Official Symbol: MAPT
• Synonyms: MAPT; microtubule-associated protein tau; DDPAC, MAPTL; FLJ31424; FTDP 17; G protein beta1/gamma2 subunit interacting factor 1; MGC138549; microtubule associated protein tau; isoform 4; MSTD; MTBT1; MTBT2; PPND; tau; TAU; PHF-tau; paired helical filament-tau; neurofibrillary tangle protein; microtubule-associated protein tau, isoform 4; G protein beta1/gamma2 subunit-interacting factor 1; DDPAC; MAPTL; FTDP-17
• Gene ID: 4137
• mRNA Refseq: NM_001123066
• Protein Refseq: NP_001116538
• MIM: 157140
• UniProt ID: P10636