Recombinant Human MAPK8IP1 Protein, MYC/DDK-tagged

• Cat.No.: MAPK8IP1-378H
• Product Overview: Recombinant human MAPK8IP1 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.

Specification

• Description: This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011].
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 77.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: mitogen-activated protein kinase 8 interacting protein 1 [ Homo sapiens ]
• Official Symbol: MAPK8IP1
• Synonyms: IB1; JIP-1; JIP1; PRKM8IP
• Gene ID: 9479
• mRNA Refseq: NM_005456.3
• Protein Refseq: NP_005447.1
• MIM: 604641
• UniProt ID: Q6NUQ9