Recombinant Human MAP4K5, GST-tagged, Active

• Cat.No.: MAP4K5-341H
• Product Overview: Recombinant full-length human KHS1 was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 135 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: KHS1 belongs to serine/threonine kinase family that has a STE20-like protein kinase domain which stimulates the stress-activated protein kinase (SAPK, also known as Jun kinase or JNK) pathway. It is a mitogen-activated protein kinase kinase kinase kinase 5, termed germinal center kinase related (GCKR). Recently, the KH domain of Escherichia coli polynucleotide phosphorylase has been reported to be necessary for autoregulation and growth at low temperature.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 [ Homo sapiens ]
• Synonyms: MAP4K5; mitogen-activated protein kinase kinase kinase kinase 5; KHS; GCKR; KHS1; MAPKKKK5; germinal center kinase-related; kinase homologous to SPS1/STE20; EC 2.7.11.1;MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5
• Gene ID: 11183
• mRNA Refseq: NM_006575
• Protein Refseq: NP_006566
• MIM: 604923
• UniProt ID: Q9Y4K4
• Chromosome Location: 14q11.2-q21
• Function: ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; small GTPase regulator activity; transferase activity