Recombinant Human MAP3K7 cell lysate

• Cat.No.: MAP3K7-1056HCL

Specification

• Species: Human
• Tag: Non
• Description: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: MAP3K7 mitogen-activated protein kinase kinase kinase 7 [ Homo sapiens ]
• Official Symbol: MAP3K7
• Synonyms: MAP3K7; mitogen-activated protein kinase kinase kinase 7; TAK1; MEKK7; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor-beta-activated kinase 1; TGF1a
• Gene ID: 6885
• mRNA Refseq: NM_003188
• Protein Refseq: NP_003179
• MIM: 602614
• UniProt ID: O43318
• Chromosome Location: 6q15
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Activation of NF-kappaB in B Cells, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; BCR signaling pathway, organism-specific biosystem
• Function: ATP binding; MAP kinase kinase kinase activity; kinase activity; magnesium ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity