Recombinant Human MAP2K2, GST-tagged, Active

• Cat.No.: MAP2K2-350H
• Product Overview: Recombinant full-length human MEK2 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 71 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: MEK2 is the member of MAPK kinase (MAPKK) family of signaling protein kinases. MEK2 is a dual-specificity kinase that activates the extracellular signal-regulated kinase (ERK) and mitogen-activated protein (MAP) kinase upon agonist binding to receptors. MEK2 plays a key role in the Ras/Raf/MEK/ERK mitogen-activated protein kinase (MAPK) signaling pathways. Approximately 30% of all human cancers have a constitutively activated MAPK pathway, and constitutive activation of MEK2 results in cellular transformation. The ERK/MAP kinase cascade regulates cell growth and differentiation.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: MAP2K2 mitogen-activated protein kinase kinase 2 [ Homo sapiens ]
• Synonyms: MAP2K2; mitogen-activated protein kinase kinase 2; MEK2; MKK2; MAPKK2; PRKMK2; FLJ26075; MAPK/ERK kinase 2; MAP kinase kinase 2; ERK activator kinase 2; mitogen-activated protein kinase kinase 2, p45; dual specificity mitogen-activated protein kinase kinase 2; EC 2.7.12.2; mitogen-activated protein kinase kinase 2
• Gene ID: 5605
• mRNA Refseq: NM_030662
• Protein Refseq: NP_109587
• MIM: 601263
• UniProt ID: P36507
• Chromosome Location: 19p13.3
• Pathway: Acute myeloid leukemia; B cell receptor signaling pathway; Bladder cancer; Chronic myeloid leukemia; Endometrial cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Gap junction; Glioma; GnRH signaling pathway; Insulin signaling pathway; Long-term depression; Long-term potentiation; MAPK signaling pathway; Melanogenesis; Melanoma; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Non-small cell lung cancer; Pathways in cancer; Prion diseases; Prostate cancer; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway; Thyroid cancer; Toll-like receptor signaling pathway; VEGF signaling pathway; Vascular smooth muscle contraction
• Function: ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity