Recombinant Human MAP2K2, GST-tagged, Active
Cat.No. : | MAP2K2-350H |
Product Overview : | Recombinant full-length human MEK2 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 71 kDa. |
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Species : | Human |
Source : | Sf9 Cells |
Tag : | GST |
Description : | MEK2 is the member of MAPK kinase (MAPKK) family of signaling protein kinases. MEK2 is a dual-specificity kinase that activates the extracellular signal-regulated kinase (ERK) and mitogen-activated protein (MAP) kinase upon agonist binding to receptors. MEK2 plays a key role in the Ras/Raf/MEK/ERK mitogen-activated protein kinase (MAPK) signaling pathways. Approximately 30% of all human cancers have a constitutively activated MAPK pathway, and constitutive activation of MEK2 results in cellular transformation. The ERK/MAP kinase cascade regulates cell growth and differentiation. |
Sequence : | Full-length. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name | MAP2K2 mitogen-activated protein kinase kinase 2 [ Homo sapiens ] |
Synonyms | MAP2K2; mitogen-activated protein kinase kinase 2; MEK2; MKK2; MAPKK2; PRKMK2; FLJ26075; MAPK/ERK kinase 2; MAP kinase kinase 2; ERK activator kinase 2; mitogen-activated protein kinase kinase 2, p45; dual specificity mitogen-activated protein kinase kinase 2; EC 2.7.12.2; mitogen-activated protein kinase kinase 2 |
Gene ID | 5605 |
mRNA Refseq | NM_030662 |
Protein Refseq | NP_109587 |
MIM | 601263 |
UniProt ID | P36507 |
Chromosome Location | 19p13.3 |
Pathway | Acute myeloid leukemia; B cell receptor signaling pathway; Bladder cancer; Chronic myeloid leukemia; Endometrial cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Gap junction; Glioma; GnRH signaling pathway; Insulin signaling pathway; Long-term depression; Long-term potentiation; MAPK signaling pathway; Melanogenesis; Melanoma; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Non-small cell lung cancer; Pathways in cancer; Prion diseases; Prostate cancer; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway; Thyroid cancer; Toll-like receptor signaling pathway; VEGF signaling pathway; Vascular smooth muscle contraction |
Function | ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity |
◆ Recombinant Proteins | ||
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MAP2K2-968HAF488 | Recombinant Human MAP2K2 Protein, GST-tagged, Alexa Fluor 488 conjugated | +Inquiry |
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MAP2K2-3560R | Recombinant Rat MAP2K2 Protein | +Inquiry |
◆ Cell & Tissue Lysates | ||
MAP2K2-613HCL | Recombinant Human MAP2K2 cell lysate | +Inquiry |
Not For Human Consumption!
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