Recombinant Human mannose binding lectin 2 Protein, His&Flag tagged

• Cat.No.: MBL2-075H
• Product Overview: Recombinant human MBL2 protein (P11226) (Ala 108-Ile 248) with both His and Flag tag at the C-terminus was expressed in HEK293.

Specification

• Description: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response.
• Source: HEK293
• Species: Human
• Tag: C-His&Flag
• Protein length: 108-248aa
• Molecular Mass: 16 kDa
• Endotoxin: Less than 1.0 EU/μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.

Gene Information

• Gene Name: MBL2 mannose binding lectin 2 [ Homo sapiens (human) ]
• Official Symbol: MBL2
• Synonyms: MBL2; mannose-binding lectin (protein C) 2, soluble; mannose binding lectin (protein C) 2, soluble (opsonic defect), MBL; mannose-binding protein C; COLEC1; collectin-1; mannan-binding lectin; mannose-binding lectin 2, soluble (opsonic defect); mannose-binding lectin (protein C) 2, soluble (opsonic defect); MBL; MBP; MBP1; MBL2D; MBP-C; HSMBPC; MGC116832; MGC116833
• Gene ID: 4153
• mRNA Refseq: NM_000242
• Protein Refseq: NP_000233
• MIM: 154545
• UniProt ID: P11226