Recombinant Human MANF Protein, MYC/DDK-tagged

• Cat.No.: MANF-327H
• Product Overview: Recombinant human MANF protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 18.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: mesencephalic astrocyte derived neurotrophic factor [ Homo sapiens ]
• Official Symbol: MANF
• Synonyms: ARMET; ARP
• Gene ID: 7873
• mRNA Refseq: NM_006010.4
• Protein Refseq: NP_006001.3
• MIM: 601916
• UniProt ID: P55145