Recombinant Human M6PR, His-tagged

• Cat.No.: M6PR-182H
• Product Overview: M6PR, 27-185aa, Human, His tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 27-185aa
• Description: M6PR is a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. This protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. Recombinant human M6PR protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques..
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
• Molecular Mass: 20.3kDa (182aa) confirmed by MALDI-TOF
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSTEEKTCD LVGEKGKESE KELALVKRLK PLFNKSFEST VGQGSDTYIY IFRVCREAGN HTSGAGLVQI NKSNGKETVV GRLNETHIFN GSNWIMLIYK GGDEYDNHCG KEQRRAVVMI SCNRHTLADN FNPVSEERGK VQDCFYLFEM DSSLACSPEI SH
• Purity: >85% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml (determined by BRADFORD assay)

Gene Information

• Gene Name: M6PR mannose-6-phosphate receptor (cation dependent) [ Homo sapiens ]
• Official Symbol: M6PR
• Synonyms: M6PR; mannose-6-phosphate receptor (cation dependent); cation-dependent mannose-6-phosphate receptor; Mr 46,000 Man6PR; CD Man-6-P receptor; small mannose 6-phosphate receptor; 46-kDa mannose 6-phosphate receptor; SMPR; MPR46; CD-MPR; MPR 46; MPR-46; FLJ32994
• Gene ID: 4074
• mRNA Refseq: NM_001207024
• Protein Refseq: NP_001193953
• MIM: 154540
• UniProt ID: P20645
• Chromosome Location: 12
• Pathway: Clathrin derived vesicle budding, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Lysosome Vesicle Biogenesis, organism-specific biosystem; Membrane Trafficking, organism-specific biosystem; Phagosome, organism-specific biosystem; Phagosome, conserved biosystem
• Function: mannose binding; mannose transmembrane transporter activity; receptor activity; transmembrane signaling receptor activity