M6PR
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Official Full Name
mannose-6-phosphate receptor (cation dependent) -
Overview
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. -
Synonyms
M6PR;mannose-6-phosphate receptor (cation dependent);cation-dependent mannose-6-phosphate receptor;46 kDa mannose 6 phosphate receptor;Cation dependent mannose 6 phosphate receptor;Cation dependent mannose 6 phosphate receptor precursor;Cation independent mannose 6 phosphate receptor;CD Man 6 P receptor;CD MPR;CD222;CIMPR;FLJ32994;IGFR2;Insulin like growth factor 2 receptor;M6PR protein;Man6PR;Mannose 6 phosphate receptor;MPR 46;MPR46;MPRD;MPRI;SMPR;Mr 46,000 Man6PR;CD Man-6-P receptor;small mannose 6-phosphate receptor;46-kDa mannose 6-phosphate receptor;CD-MPR;MPR-46
Recombinant Proteins
- Zebrafish
- Human
- Rat
- Mouse
- Bovine
- Mus musculus
- Mammalian Cells
- E.coli
- Human Cells
- HEK293
- His
- Fc
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
M6PR involved in several pathways and played different roles in them. We selected most pathways M6PR participated on our site, such as Lysosome,Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with M6PR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | TPP1,ABCB9,SCARB2,HYAL1,CTSM,ACP5B,HEXB,DNASE2A,CTSSA,CTSF |
| Phagosome | TUBA3D,HLA-DRB3,TUBA8L3,ATP6V0A2,ATP6V1B1,ATP6V1E2,TUBA4A,TUBA3B,Itgam&Itgb2,HGS |
Protein Function
M6PR has several biochemical functions, for example, mannose binding,mannose transmembrane transporter activity,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by M6PR itself. We selected most functions M6PR had, and list some proteins which have the same functions with M6PR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane signaling receptor activity | CLEC2D,RYK,LAG3,FZD3A,TLR1,HIST2H3C2,OR2A4,TLR2-1,ERBB3,CELSR3 |
| mannose binding | MBL2,LMAN2L,CD209,CLEC4M,CD209C,LMAN2,Acr,MANBA,COLEC10,CLN5 |
Interacting Protein
M6PR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with M6PR here. Most of them are supplied by our site. Hope this information will be useful for your research of M6PR.
GGA3;GGA1;15-deoxy-delta(12,14;cona_canen;P;TCP1;OLR1;LRP2
Resources
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References
- Bin, BH; Bhin, J; et al. Hyperosmotic Stress Reduces Melanin Production by Altering Melanosome Formation. PLOS ONE 9:-(2014).
- Frei, AP; Jeon, OY; et al. Direct identification of ligand-receptor interactions on living cells and tissues. NATURE BIOTECHNOLOGY 30:997-+(2012).
