Recombinant Human LRPAP1 Protein, His-tagged

• Cat.No.: LRPAP1-2017H
• Product Overview: Recombinant Human LRPAP Protein is produced by E. coli expression system. The target protein is expressed with sequence (Tyr35-Leu357) of human LRPAP (Accession #NP_002328.1) fused with an initial Met at the N-terminus and a 6×His tag at the C-terminus.

Specification

• Description: This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5 % mannitol.
• Protein length: Tyr35-Leu357
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: > 90% as determined by SDS-PAGE
• Stability: Samples are stable for up to twelve months from date of receipt at -70ºC.
• Storage: Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: LRPAP1 low density lipoprotein receptor-related protein associated protein 1 [ Homo sapiens ]
• Official Symbol: LRPAP1
• Synonyms: LRPAP1; low density lipoprotein receptor-related protein associated protein 1; A2MRAP, low density lipoprotein related protein associated protein 1 (alpha 2 macroglobulin receptor associated protein 1); alpha-2-macroglobulin receptor-associated protein; HBP44; alpha-2-MRAP; lipoprotein receptor associated protein; alpha-2-macroglobulin receptor-associated protein 1; low density lipoprotein receptor-related protein-associated protein 1; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1); RAP; MRAP; A2RAP; A2MRAP; MGC138272
• Gene ID: 4043
• mRNA Refseq: NM_002337
• Protein Refseq: NP_002328
• MIM: 104225
• UniProt ID: P30533

Reviews

12/17/2021

This technical support is invaluable, especially for researchers who may be new to working with LRPAP1 protein or if they encounter specific difficulties while conducting their experiments.

12/20/2020

They can offer guidance on experimental design, protocol optimization, and troubleshooting, helping researchers overcome any challenges encountered during their trials.

06/20/2016

the manufacturer's technical expertise can be advantageous to researchers.

Q&As

Can LRPAP1 be a target for therapeutic interventions, and if so, in what diseases?

LRPAP1 may be a potential therapeutic target in diseases where its interactions with LRP1 play a crucial role, such as neurodegenerative disorders, cardiovascular diseases, and certain cancers.

In what ways does LRPAP1 influence the immune system, and how might this be relevant in clinical applications?

LRPAP1 has been implicated in immune system regulation, and its interactions with LRP1 may impact immune responses, suggesting potential applications in immunotherapy.

Are there any known genetic variations or mutations in the LRPAP1 gene associated with diseases?

Genetic variations or mutations in the LRPAP1 gene have been investigated in the context of certain diseases, and understanding these variations may provide insights into disease susceptibility and progression.

How does LRPAP1 contribute to the regulation of lipoprotein metabolism and cardiovascular health?

LRPAP1 plays a role in lipoprotein metabolism by influencing the function of LRP1, a receptor involved in the clearance of lipoproteins from the circulation, thus impacting cardiovascular health.

How might the study of LRPAP1 contribute to personalized medicine approaches in the future?

Understanding the role of LRPAP1 in various diseases may contribute to personalized medicine by identifying individuals who could benefit from targeted therapies based on their specific genetic or molecular profiles.