Recombinant Human LRP6 Protein, N-His tagged, Avi-biotinylated

• Cat.No.: LRP6-7875HB
• Product Overview: Recombinant Human LRP6 Protein with N-His tag and Avi-biotin was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
• Form: Lyophilized
• Molecular Mass: 32.2 kDa
• AA Sequence: MGSSHHHHHHGLNDIFEAQKIEWHESSGLVPRGSHMASMTGGQQMGRGSEFWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGG
• Endotoxin: <1 EU/μg by LAL
• Purity: > 90% by SDS-PAGE
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Lyophilized from PBS, pH 7.4, 5% trehalose, 5% mannitol

Gene Information

• Gene Name: LRP6 LDL receptor related protein 6 [ Homo sapiens (human) ]
• Official Symbol: LRP6
• Synonyms: LRP6; LDL receptor related protein 6; ADCAD2; STHAG7; low-density lipoprotein receptor-related protein 6; LRP-6
• Gene ID: 4040
• mRNA Refseq: NM_002336
• Protein Refseq: NP_002327
• MIM: 603507
• UniProt ID: O75581