Recombinant Human LOXL2, GST-tagged

• Cat.No.: LOXL2-150H
• Product Overview: Recombinant human LOXL2 (519-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 519-end a.a.
• Description: LOXL2 is a member of the lysyl oxidase gene family which is essential for the biogenesis of connective tissue. LOXL2 encodes an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. LOXL2 may play an important role in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. LOXL2 may mediate fibroblast activation through enzymatic crosslinking of fibrillar collagen and local matrix tention, resulting in activation of TGF?1 signaling.
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~65 kDa
• Purity: >75% by densitometry
• Applications: Western Blot
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μl

Gene Information

• Gene Name: LOXL2 lysyl oxidase-like 2 [ Homo sapiens ]
• Official Symbol: LOXL2
• Synonyms: LOXL2; lysyl oxidase-like 2; lysyl oxidase homolog 2; WS9 14; lysyl oxidase related 2; lysyl oxidase-like protein 2; lysyl oxidase-related protein 2; lysyl oxidase-related protein WS9-14; LOR2; WS9-14
• Gene ID: 4017
• mRNA Refseq: NM_002318
• Protein Refseq: NP_002309
• MIM: 606663
• UniProt ID: Q9Y4K0
• Chromosome Location: 8p21.3
• Function: copper ion binding; electron carrier activity; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; scavenger receptor activity