LOXL2
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Official Full Name
lysyl oxidase-like 2 -
Overview
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the;biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first;step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus;end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function.;The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor;suppression, cell growth control, and chemotaxis to each member of the family. -
Synonyms
LOXL2;lysyl oxidase-like 2;lysyl oxidase homolog 2;WS9 14;LOR 2;LOR2;LOX L2;LOXL 2;LOXL2_HUMAN;Lysyl oxidase like 2;Lysyl oxidase like protein 2;Lysyl oxidase related 2;Lysyl oxidase related protein 2;Lysyl oxidase related protein WS9 14;Lysyl oxidase-like protein 2;Lysyl oxidase-related protein 2;Lysyl oxidase-related protein WS9-14;OTTHUMP00000224942;WS9-14
Recombinant Proteins
- Human
- Mouse
- Rat
- Human Cell
- E.coli
- HEK293
- Mammalian cells
- CHO
- Sf9 Insect Cell
- Insect Cell
- Mammalian Cell
- Yeast
- E. coli
- Wheat Germ
- His
- GST
- FLAG
- Fc
- His&Avi
- Non
- His&Fc&Avi
Involved Pathway
LOXL2 involved in several pathways and played different roles in them. We selected most pathways LOXL2 participated on our site, such as Assembly of collagen fibrils and other multimeric structures,Collagen formation,Crosslinking of collagen fibrils, which may be useful for your reference. Also, other proteins which involved in the same pathway with LOXL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Extracellular matrix organization | EMID2,DMD,LAMB1B,CTSK,LOXL1,COL13A1,COL8A1A,PCOLCEA,TLDC2,CTS7 |
| Elastic fibre formation | BMP10,EFEMP1,FBN2,EFEMP2,MFAP5,LOXL3,LTBP3,MFAP2,MFAP4,LTBP2 |
| Collagen formation | COL9A3,COL4A3,COL1A2,MMP20,COL4A6,LEPREL2,CD151,LOXL1,COL1A1,PCOLCEA |
| Crosslinking of collagen fibrils | ABHD1,TLL1,LOXL4,LOX,BMP1B,TLL2,BMP1A,LOXL1,LOXL3,PCOLCE |
| Assembly of collagen fibrils and other multimeric structures | MMP20,BMP1,COL5A3A,COL4A3,COL6A3,CD151,LOXL1,CTSB,COL8A1,DST |
Protein Function
LOXL2 has several biochemical functions, for example, chromatin binding,copper ion binding,electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LOXL2 itself. We selected most functions LOXL2 had, and list some proteins which have the same functions with LOXL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| electron carrier activity | COX7A2A,COX7A1,GLRX3,ACADL,CIAPIN1,GLRX5,POR,ME2,GSR,GPX2 |
| copper ion binding | ATOX1,LOXL5B,APOA4,HEPHL1,P2RX2,S100U,ANG,SOD1,TYR,SERPINB1A |
| oligosaccharide binding | SELE,CHID1,DCBLD1,SELP,RS1A |
| methylated histone binding | ING2,CBX4,PHF8,RRP8,ATRX,FAM156A,WDR92,PHF19,ING1,RBBP5 |
| scavenger receptor activity | SCARA5,TMPRSS5,TMPRSS4A,PRG4,CD5L,TMPRSS4,CFI,TMPRSS13B,HHIPL1,SCARA3 |
| protein binding | RNMT,CSRNP2,GDI2,ZHX1,NEUROG1,BTRC,HEATR5B,CD276,TPD52L3,HIST1H4J |
| chromatin binding | YBX2,CAMTA2,KDM6B,TOX2,SP110,SNAI2,TADA2A,HDAC3,CCNT1,CHAF1B |
| transcription corepressor activity | C1D,SP100,HDAC5,SETD8,BCL11A,TRIM28,KLF12,DRAP1,NPAT,ERF |
| protein-lysine 6-oxidase activity | LOXL3,LOXL2A,LOX,LOXL4,POLR1B,ABHD1,LOXL2B |
Interacting Protein
LOXL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LOXL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LOXL2.
MARCKSL1;PDIA3;EGFL7
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References
- Meissner, EG; McLaughlin, M; et al. Longitudinal hepatic and PBMC gene expression profiling of HIV and/or HCV-infected patients with advanced liver disease treated with simtuzumab, an anti-LOXL2 antibody. HEPATOLOGY 60:421A-421A(2014).
- Barker, HE; Bird, D; et al. Tumor-Secreted LOXL2 Activates Fibroblasts through FAK Signaling. MOLECULAR CANCER RESEARCH 11:1425-1436(2013).