Recombinant Human LMNB1 protein, His-tagged

• Cat.No.: LMNB1-266H
• Product Overview: Recombinant Human LMNB1(Ser52~Gly233) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants.
• Source: E. coli
• Species: Human
• Tag: His
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 24.2kDa
• Protein length: Ser52~Gly233
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: > 95%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: LMNB1 lamin B1 [ Homo sapiens ]
• Official Symbol: LMNB1
• Synonyms: LMNB1; lamin B1; lamin-B1; LMN; ADLD; LMN2; LMNB; MGC111419
• Gene ID: 4001
• mRNA Refseq: NM_001198557
• Protein Refseq: NP_001185486
• MIM: 150340
• UniProt ID: P20700
• Chromosome Location: 5q23.2
• Pathway: Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Breakdown of the nuclear lamina, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem
• Function: phospholipase binding; structural molecule activity