Recombinant Human LMNB1

• Cat.No.: LMNB1-29911TH
• Product Overview: Recombinant fragment corresponding to amino acids 107-186 of Human Lamin B1 with a N terminal proprietary tag; predicted MWt 34.43 kDa inclusive of tag.

Specification

• Description: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).
• Protein length: 80 amino acids
• Molecular Weight: 34.430kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: LGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLAD
• Sequence Similarities: Belongs to the intermediate filament family.
• Tag: Non

Gene Information

• Gene Name: LMNB1 lamin B1 [ Homo sapiens ]
• Official Symbol: LMNB1
• Synonyms: LMNB1; lamin B1; lamin-B1
• Gene ID: 4001
• mRNA Refseq: NM_001198557
• Protein Refseq: NP_001185486
• MIM: 150340
• Uniprot ID: P20700
• Chromosome Location: 5q23.2
• Pathway: Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Breakdown of the nuclear lamina, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem
• Function: phospholipase binding; structural molecule activity