Recombinant Human LMNA

• Cat.No.: LMNA-28299TH
• Product Overview: Recombinant full length Human mature protein Lamin A, MW 70 kDa,

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
• Tissue specificity: In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle celle (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degener
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the intermediate filament family.
• Full Length: Full L.

Gene Information

• Gene Name: LMNA lamin A/C [ Homo sapiens ]
• Official Symbol: LMNA
• Synonyms: LMNA; lamin A/C; cardiomyopathy, dilated 1A (autosomal dominant) , CMD1A, lamin A/C like 1 , LGMD1B, limb girdle muscular dystrophy 1B (autosomal dominant) , LMN1, LMNL1, PRO1, progeria 1 (Hutchinson Gilford type); prelamin-A/C; HGPS
• Gene ID: 4000
• mRNA Refseq: NM_005572
• Protein Refseq: NP_005563
• MIM: 150330
• Uniprot ID: P02545
• Chromosome Location: 1q22
• Pathway: Activation of Chaperones by IRE1alpha, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem
• Function: protein binding; structural molecule activity; structural molecule activity