Recombinant Human Liver X receptor-LBD, His-tagged

• Cat.No.: NR1H2-010N
• Product Overview: Produced by transient expression of LXR in non-transgenic plants. Recombinant human LXR contains a 6-His-tag at the N-terminal end and is purified by sequential chromatography (FPLC). Contains no animal–derived components or impurities.

Specification

• Cat. No.: NR1H2-010N
• Description: Liver X Receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. There are two subtypes of LXRs, LXRα and LXRβ. The LXRs are ligand-dependent transcription factors that form permissive heterodimers with the retinoid X receptor (RXR). LXR- member of Nuclear Receptor Family is activated by certain oxysterol derivatives of cholesterol. They play an important role in cholesterol, lipid, and carbohydrate metabolism.
• Source: Nicotiana benthamiana
• Sequence: HHHHHHSSGIEGRGRLIKHMTPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
• Formulation: Lyophilized from a Tris HCl 20mM buffer at pH 8, 0.1% SDS.
• Molecularformula: C1422H2249N409O415S8
• Extinction coefficient: E0.1% = 0.581 (A280 nm).
• Molecular weight: 31.9 kDa (201-461 amino acids)
• Purity: > 97% by SDS-PAGE gel.
• Endotoxin level: < 0.04 EU/μg protein (LAL method)
• Storage: This lyophilized preparation is stable at 2-8º C. For long storage should be kept at -20º C and it is recommended to add a carrier protein (0.1% HSA or BSA). Repeated freezing and thawing is not recommended.

Gene Information

• Gene Name: NR1H2 nuclear receptor subfamily 1, group H, member 2 [ Homo sapiens ]
• Official Symbol: NR1H2
• Synonyms: NR1H2; nuclear receptor subfamily 1, group H, member 2; NER; UNR; LXRB; LXR-b; NER-I; RIP15; liver X receptor beta; liver X receptor-beta; nuclear orphan receptor LXR-beta; oxysterols receptor LXR-beta; steroid hormone-nuclear receptor NER; ubiquitously-expressed nuclear receptor; LX receptor beta
• Gene ID: 7376
• mRNA Refseq: NM_007121
• Protein Refseq: NP_009052
• MIM: 600380
• UniProt ID: P55055
• Chromosome Location: 19q13.3
• Function: Gene Expression