NR1H2
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Official Full Name
nuclear receptor subfamily 1, group H, member 2 -
Overview
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010] -
Synonyms
NR1H2;nuclear receptor subfamily 1, group H, member 2;NER;UNR;LXRB;LXR-b;NER-I;RIP15;oxysterols receptor LXR-beta;LX receptor beta;nuclear receptor NER;liver X nuclear receptor beta;nuclear orphan receptor LXR-beta;steroid hormone-nuclear receptor NER;ubiquitously-expressed nuclear receptor
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Bovine
- E.coli
- Nicotiana Benthamiana
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- E. coli
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- GST
- His&T7
- Myc&DDK
- His&Fc&Avi
- StrepII
- Flag
Involved Pathway
NR1H2 involved in several pathways and played different roles in them. We selected most pathways NR1H2 participated on our site, such as Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR1H2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin resistance | PIK3R3B,PPARGC1B,PRKAB1A,PIK3R3A,RPS6KA3A,PRKAG2A,NOS3,PIK3CD,PRKCQ,GFPT1 |
Protein Function
NR1H2 has several biochemical functions, for example, ATPase binding,DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR1H2 itself. We selected most functions NR1H2 had, and list some proteins which have the same functions with NR1H2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATPase binding | PEX19,METTL21A,NSFL1C,WFS1,ABCA1,CHMP4A,PDE4D,NKAIN1,EZR,RAB4A |
| retinoid X receptor binding | MED25,PPARG,HMGA1-RS1,FUS,RARG,NR1H4,NCOA1,NSD1,NCOR1,HMGA1 |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | NR1I3,NR5A1B,Ar,PPARAA,RORA,RXRA,NR1D2,RORB,NR0B1,NR5A1 |
| zinc ion binding | PHF14,KNG1,MARCH9,MANEA,ADAM10A,CA6,PHF11,ZNF8,CLIP1,FTR43 |
| apolipoprotein A-I receptor binding | APOA1,CDC42 |
| steroid hormone receptor activity | PPARD,NR1D1,NR2F1,HNF4G,RORCA,GPR30,RXRBB,PAQR8,NR2F2,NR1D2B |
| DNA binding | PRDM9,TEAD2,PCXB,KCNA3,TAF9,RREB1,HDGFRP2,SETDB1,ZFP93,ZNF317 |
| protein binding | RBM14,VAT1L,CCDC67,CPNE7,UBAP2L,ENO1,SOCS7,CEACAM6,BOLA1,NIF3L1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | EGR2,TRP53,WT1,SMAD1,FLI1,FOXA1,NKX2-5,EBF3A,ZIC3,PGR |
Interacting Protein
NR1H2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR1H2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR1H2.
MDFI;ABCA1;CIDEA;KDM1A;SUV39H1;SPRY2;SORBS2;NPY;VIM;SMPD1;YY1;COL4A5;CDKN1A;RXRG;UBE2D1;MPP1;CHD3
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References
- Andersen, V; Vogel, U; et al. Interactions between meat intake and genetic variation in relation to colorectal cancer. GENES AND NUTRITION 10:-(2015).
- He, Q; Pu, J; et al. Activation of Liver-X-Receptor alpha But Not Liver-X-Receptor beta Protects Against Myocardial Ischemia/Reperfusion Injury. CIRCULATION-HEART FAILURE 7:1032-U315(2014).
