Recombinant Human Lin-7 Homolog A (C. elegans), His-tagged

• Cat.No.: LIN7A-7189H
• Product Overview: Recombinant human Lin7A protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 28.4 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-233aa
• Description: Lin7A, also as known as MALS1 or VELI1, belongs to the lin-7 family. This protein contains 1 L27 domain and 1 PDZ (DHR) domain. It plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Lin7A is expressed in brain, testis, kidney, placenta and liver.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol,1mM DTT.
• Molecular Mass: 28.4 kDa (256aa) confirmed by MALDI-TOF.
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMLKPSVT SAPTADMATL TVVQPLTLDR DVARAIELLE KLQESGEVPV HKLQSLKKVL QSEFCTAIRE VYQYMHETIT VNGCPEFRAR ATAKATVAAF AASEGHSHPR VVELPKTDEG LGFNVMGGKE QNSPIYISRI IPGGVAERHG GLKRGDQLLS VNGVSVEGEH HEKAVELLKA AKDSVKLVVR YTPKVLEEME ARFEKLRTAR RRQQQQLLIQ QQQQQQQQQT QQNHMS
• Purity: >90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: LIN7A lin-7 homolog A (C. elegans) [ Homo sapiens ]
• Official Symbol: LIN7A
• Synonyms: LIN7A; lin-7 homolog A (C. elegans); LIN7; VELI1; LIN-7A; MALS-1; TIP-33; in lin-7 homolog A; hLin-7; veli-1; mammalian LIN-7 1; vertebrate LIN7 homolog 1; tax interaction protein 33; vertebrate lin-7 homolog 1; mammalian lin-seven protein 1; Protein lin-7 homolog A; MALS1
• Gene ID: 8825
• mRNA Refseq: NM_004664
• Protein Refseq: NP_004655
• MIM: 603380
• UniProt ID: O14910
• Chromosome Location: 12q21
• Function: L27 domain binding; protein binding