Recombinant Human LILRB4 protein, His-Avi-tagged

• Cat.No.: LILRB4-309H
• Product Overview: Human LILRB4 Protein is expressed from mammalian with His and Avi Tag at the C-terminal. It contains Gln 22-Glu 259.

Specification

• Species: Human
• Source: HEK293
• Tag: Avi&His
• Protein Length: Gln 22-Glu 259
• Description: LILRB4,also known as CD85k and LIR-5, ILT3, is an approximately 60 kDa transmembrane glycoprotein that negatively regulates immune cell activation. Mature human ILT3 consists of a 238 amino acid (aa) extracellular domain with two Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 3 immunoreceptor tyrosine-based inhibitory motifs (ITIM).LILRB4 is receptor for class I MHC antigens. Recognizes a broad spectrum of HLAA, HLA-B, HLA-C and HLA-G alleles.
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 28.6KDa. Due to glycosylation, the protein migrates to 38- 42KDa based on Bis-Tris PAGE result.
• Endotoxin: Less than 0.5EU per ug by the LAL method.
• Purity: > 95% as determined by SDS-PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: LILRB4 leukocyte immunoglobulin like receptor B4 [ Homo sapiens (human) ]
• Official Symbol: LILRB4
• Synonyms: CD85 antigen-like family member K; CD85k antigen; CD85k; HM18; ILT3; ILT-3; ILT3CD85K; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains); LILRB4; LIR5; LIR5LILRB5; LIR-5subfamily B, member 4; member 4
• Gene ID: 11006
• mRNA Refseq: NM_001278426.3
• Protein Refseq: NP_001265355.2
• MIM: 604821
• UniProt ID: Q8NHJ6