Recombinant Human leukocyte immunoglobulin like receptor B4 Protein, His&Flag tagged

• Cat.No.: LILRB4-132H
• Product Overview: Recombinant human LILRB4/ILT3 protein (Q8NHJ6) (Gln 22-Glu 259) with both His and Flag tag at the C-terminus was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: Flag&His
• Protein Length: 22-259aa
• Description: Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance. Receptor for FN1. Receptor for apolipoprotein APOE. Receptor for ALCAM/CD166. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production. This inhibition of monocyte activation occurs at least in part via binding to FN1. Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells. Induces up-regulation of CD86 on dendritic cells. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation.
• Tag: C-His&Flag
• Molecular Mass: 29 kDa
• Endotoxin: Less than 1.0 EU/μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.

Gene Information

• Gene Name: LILRB4 leukocyte immunoglobulin like receptor B4 [ Homo sapiens (human) ]
• Official Symbol: LILRB4
• Synonyms: HM18; ILT3; LIR5; CD85K; LIR-5; LILRB5
• Gene ID: 11006
• mRNA Refseq: NM_006847.3
• Protein Refseq: NP_006838.3
• MIM: 604821
• UniProt ID: Q8NHJ6