Recombinant Human LILRA3 protein, His-Avi-tagged

• Cat.No.: LILRA3-868H
• Product Overview: Human LILRA3 Protein is expressed from mammalian with His and Avi Tag at the C-terminal. It contains Gly24-Glu439.

Specification

• Description: Human LILRA3, also known as Leukocyte Ig-like receptor 4 (LIR-4), CD85 antigen-like family member E, Immunogobulin-like transcript 6 (ILT-6) and monocyte inhibitory receptor HM43/HM31, is a 70 kD Ig superfamily member that belongs to the leukocyte receptor complex/cluster. Mature LILRA3 is 416 amino acids (aa) in length and contains four C2-type Ig-like domains. Unlike other LILR family members, LILRA3 is actively secreted. LILRA3 acts as soluble receptor for class I MHC antigens. LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.
• Source: HEK293
• Species: Human
• Tag: His&Avi
• Form: Supplied as 0. 22um filtered solution in 20mM PB, 150mM NaCl (pH 7. 4).
• Molecular Mass: The protein has a predicted MW of 47. 9 kDa. Due to glycosylation, the protein migrates to 68- 72KDa based on Bis-Tris PAGE result.
• Protein length: Gly24-Glu439
• Endotoxin: Less than 0. 01EU per ug by the LAL method.
• Purity: > 95% as determined by SDS-PAGE; > 90% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 [ Homo sapiens ]
• Official Symbol: LILRA3
• Synonyms: CD85 antigen-like family member E; CD85e antigen; CD85e; HM31; HM43; ILT6; ILT-6; ILT6CD85e; Immunoglobulin-like transcript 6; leucocyte immunoglobulin-like receptor; Leukocyte immunoglobulin-like receptor 4; leukocyte immunoglobulin-like receptor A3; leukocyte immunoglobulin-like receptor subfamily A member 3; leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member3; LILRA3; LIR4; LIR4CD85E; LIR-4HM43e3; Monocyte inhibitory receptor HM43/HM31
• Gene ID: 11026
• mRNA Refseq: NM_001172654. 2
• Protein Refseq: NP_001166125. 1
• MIM: 604818
• UniProt ID: Q8N6C8