Recombinant Human LIG1, His-tagged

Cat.No. : LIG1-26930TH
Product Overview : Recombinant fragment, corresponding to amino acids 484-919 of Human DNA Ligase I with a N terminal His tag; predicted MWt 50kDa:
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Species : Human
Source : E.coli
Tag : His
ProteinLength : 484-919 a.a.
Description : LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process.Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.
Conjugation : HIS
Form : Lyophilised:Reconstitution with 96 μl aqua dest.
Storage buffer : Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : GKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEH GLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEA AFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYP DIISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLT TRKRKEVDASEIQVQVCLYAFDLIYLNGESLVREPLSR RRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSV KDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGV GDTLDLVVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAI CKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVI PDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGIS LRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQQGEDSGSDPEDTY
Gene Name LIG1 ligase I, DNA, ATP-dependent [ Homo sapiens ]
Official Symbol LIG1
Synonyms LIG1; ligase I, DNA, ATP-dependent; DNA ligase 1;
Gene ID 3978
mRNA Refseq NM_000234
Protein Refseq NP_000225
MIM 126391
Uniprot ID P18858
Chromosome Location 19q13.2-q13.3
Pathway Base Excision Repair, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem;
Function ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligase activity; ligase activity;

Not For Human Consumption!

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