Recombinant Human LIFR protein, His-tagged

• Cat.No.: LIFR-2818H
• Product Overview: Recombinant Human LIFR aa. (Trp522~Phe691 (Accession # P42702)) fused with N-terminal His tag was produced in E. coli cells.

Specification

• Description: This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 20.7kDa
• Protein length: Trp522~Phe691
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 5.5.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: LIFR LIF receptor alpha [ Homo sapiens (human) ]
• Official Symbol: LIFR
• Synonyms: SWS; SJS2; STWS; CD118; LIF-R; CD118 antigen; LIF receptor; leukemia inhibitory factor receptor alpha; leukemia inhibitory factor receptor
• Gene ID: 3977
• mRNA Refseq: NM_001127671.1
• Protein Refseq: NP_001121143.1
• UniProt ID: P42702